Hundreds of genes distinguish patients likely to survive advanced melanoma Nov 10, 2009
"Patients who didn't survive as long didn't have an up-regulation of those genes but tended to have higher levels of genes associated with cell proliferation, suggesting that if your cells are growing more actively, the tumor is going to grow faster.". This year melanoma is expected to strike 68,729 people in the United States, and some 8,650 people with the disease are expected to die, according to the American Cancer Society. (EurekAlert!)
Survival Of The Healthiest: Selective Eradication Of Malignant Cells Nov 6, 2009
The rationale for testing PARP inhibitors in these cancers was the recently disclosed up-regulation of ERK signals in the nucleus by activated PARP-1. However, other mechanisms are apparently involved. (Science Daily)
Stemedica Selected by World Stem Cell Summit to Present Scientific Discoveries Aug 27, 2009
Her submittal is entitled, "Up-Regulation of Wound Healing Associated Proteins in Long-Term Culture of Human Keratinocyte Precursor Cells." Dr. Kharazi's work demonstrates that long term cultivation of human keratinocytes in serum free, low-Ca++ media (SFM) leads to the increased expression of genes for wound healing-associated proteins such as fibronectin, metalloproteinase (MMP9, MMP10), and tissue-type plasminogen activator (TPA). The purpose of Dr. Kharazi's work was to determine how the... (PR Newswire)
Increased Levels Of Certain Cytokines And Chemokines Predict Onset Of Rheumatoid Arthritis Jul 1, 2009
ScienceDaily (June 30, 2009) Up-regulation of certain cytokines and chemokines (signaling molecules involved in the functioning of the immune system) can predict the development of rheumatoid arthritis (RA) three years before the onset of symptoms, according to the results of a new study presented at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark ... The results of the study showed that up-regulation of certain cytokines (specifically Th1, Th2... (Science Daily)
Why The Thumb Of The Right Hand Is On The Left Hand Side May 27, 2009
This fact may also be of importance for the diagnosis and treatment of certain cancers (basal cell carcinoma), where the constant up-regulation of the Hedgehog signal is responsible for uncontrolled cell growth. Aanstad published the findings together with her colleagues from the University of California, San Francisco in the journal Current Biology. (Science Daily)
Long-lasting Nerve Block Could Revolutionize Pain Management Apr 16, 2009
Furthermore, when the team examined expression of four genes known to be associated with nerve injury, they found no up-regulation. "If these long-acting, low-toxicity formulations of local anesthetics are shown to be effective in humans, they could have a major impact on the treatment of acute and chronic pain," says Alison Cole, PhD, of the NIH's National Institute of General Medical Sciences, which partially funded the work. (Science Daily)
Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data Mar 10, 2009
Immunofluorescence showed strong expression of keratin-6A in all layers, especially the superficial layers, of pterygium epithelium, but absent in the control, with up-regulation and nuclear accumulation of the cell adhesion molecule CD24 in the pterygium epithelium ... Recurrent disease was associated with up-regulation of sialophorin, a negative regulator of cell adhesion, and never in mitosis a-5, known to be involved in cell motility. (BioMed Central)
