Outfoxing Pox: Developing A New Class Of Vaccine Candidates Oct 18, 2009
These were compared with 4-pox a vaccine comprised of 4 protective genes from a close genetic relative of cowpox called the vaccinia virus ... (See figure 1) The 4-pox vaccine was developed by the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) as an alternative to the licensed vaccine against smallpox, known as Dryvax, (which is made from live vaccinia and presents significant risk for those with suppressed immune systems). (Science Daily)
HIV vaccine: All you wanted to know Sep 25, 2009
Polio vaccines use a weakened or killed version of the virus to prime the immune system, and smallpox was wiped out using a related, milder virus called vaccinia. But HIV is different. (India Times, India)
Eczema Patients Most At Risk For Dangerous Viral Infections Jun 30, 2009
ScienceDaily (June 29, 2009) Eczema patients at risk for serious viral infections have more severe disease, are more likely to be allergic to food and other allergens, and have a frequent history of staph infections, according to researchers at National Jewish Health and other institutions in the NIH-funded Atopic Dermatitis Vaccinia Network ... A subset of the estimated 6 million eczema patients in the United States are susceptible to widespread infections of their skin by herpes simplex and... (Science Daily)
Transplant drug stimulates immune memory Jun 22, 2009
Araki and Ahmed teamed up with Christian Larsen, MD, PhD, director of the Emory Transplant Center and chair of the Department of Surgery, to show that rapamycin had similar effects in rhesus macaques infected with vaccinia virus as in mice. That research was conducted at Emory's Yerkes National Primate Research Center. (EurekAlert!)
Promising antimicrobial attacks virus, stimulates immune system Jun 4, 2009
In a paper appearing online June 4 in the Journal of Investigative Dermatology, Michael Howell, PhD, Assistant Professor of Pediatrics, and his colleagues demonstrated that the synthetic compound CSA-13 can kill vaccinia virus in cell cultures and in mice ... "While our experiments were designed to test its ability to attack the vaccinia virus, its immune-stimulating ability was a surprising observation." ... Dr. Howell and his colleagues wanted to learn if CSA-13 could fight vaccinia virus... (EurekAlert!)
La Jolla Institute unlocks mystery of potentially fatal reaction to smallpox vaccine May 25, 2009
" The finding was published today in the online version of the Journal of Experimental Medicine in a paper entitled, "Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. " La Jolla Institute scientist Shane Crotty, Ph.D., also contributed to the study. Regarded as the deadliest disease ever known to man, smallpox was officially eradicated worldwide in 1980 and routine vaccinations against the disease ended in the U.S... (EurekAlert!)
Tissue-cultured Smallpox Vaccine Appears Promising Mar 18, 2009
"We demonstrated the immunogenicity of LC16m8 vaccine in vaccinia-naive adults by a single vaccination. LC16m8 vaccine also induces a good booster response in previously vaccinated individuals. Our study also offers supportive evidence for the safety of LC16m8 vaccine in adults; LC16m8 vaccine appears to be a viable alternative to first-, second- and other third-generation vaccines in a smallpox preparedness program," the researchers conclude ... 3, 2005) The U.S. Food and Drug Administration... (Science Daily)
